Application of automated morphometric method of estimation of expression of immunohistochemical markers in diagnostics of prostate and bladder cancer

The diagnostic significance of molecular markers was evaluated by immunohistochemical research of surgical and biopsy material of 106 patients with diseases of bladder and 57 patients with diseases of prostate. They received treatment at Scientific Research Institute of Fundamental and Clinical Uron...

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Bibliographic Details
Published inSaratovskiĭ nauchno-medit͡s︡inskiĭ zhurnal Vol. 6; no. 4; pp. 845 - 849
Main Authors Popkov V.M., Ponukalin A.N., Maslyakova G.N., Tsmokalyuk E.N., Bucharskaya A.B., Shirokov A.A., Burov A.M.
Format Journal Article
LanguageRussian
Published Saratov State Medical University 01.12.2010
Subjects
bladder cancer
diagnostic significance
immunohistochemistry
molecular markers
prostate cancer
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Summary:The diagnostic significance of molecular markers was evaluated by immunohistochemical research of surgical and biopsy material of 106 patients with diseases of bladder and 57 patients with diseases of prostate. They received treatment at Scientific Research Institute of Fundamental and Clinical Uronephrology with monoclonal antibodies: Ki-67, PCNA, p63 (markers of proliferative activity), p53 (suppressor of tumor growth), Bcl-2, Bax (markers of apoptosis), EGFR (receptor of epidermal growth factors), PSA, PSMA, AMACR (prostate-specific antigens) and cytokeratin profile. The morphometric research was conducted on the basis of automated analysis system of digital images Ariol SL50 (Genetix)
ISSN:1995-0039
2076-2518