Antibiotic resistance of Helicobacter pylori:a multicenter prospective analysis

• Published in: Ji chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics Vol. 40; no. 12; pp. 1661 - 1665
• Main Author: YE Shan-shan, LI Jun-da, ZHOU Ying-sheng, LIU Lu, WU Jian-wei, LYU Zhi-wu, LIU Jin-tao
• Format: Journal Article
• Language: Chinese
• Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College 01.12.2020
• Subjects: helicobacter pylori|antibiotics|resistance
• ISSN: 1001-6325

Objective To investigate the infection of Helicobacter pylori (Hp) and its resistance to six kinds of antibiotics in Shenzhen. Methods Urease test and Hp cultivation were performed in 5 080 patients with gastrointestinal discomfort in three hospitals in Shenzhen, and antibiotic sensitivity test of agar dilution was performed. Results Among the 5 080 patients, a total of 3 203 patients were Hp positive, with a positive rate of 63.05%. The resistance rate of 3 203 Hp strains to antibiotics was metronidazole (MNZ)(99.6%),amoxicillin(AMX)(30.5%),clarithromycin(CAM)(10.6%), doxycycline (DOX) (0.3%), furazolidone(FR) (0.2%), and levofloxacin(LVX) (0.1%). The rates of total sensitivity to Hp was 0.18%, single drug resistance, double and multiple drug resistance were 62.06%, 33.94% and 3.81%, respectively. MNZ and AMX had the highest double drug resistance (26.69%), while MNZ, CAM and AMX had the highest triple drug resistance (3.68%). The age ≤40 years seems to be a factor for single antibiotic resistance, while the