Multidimensional screening and intervention program for neurocognitive disorder in vascular and multimorbid outpatients: Study protocol for a randomized clinical trial

• Published in: PloS one Vol. 19; no. 7; p. e0306256
• Main Authors: Cira Fundarò, Nicolò Granata, Silvia Traversoni, Valeria Torlaschi, Roberto Maestri, Marina Maffoni, Paola Baiardi, Federica Grossi, Michelangelo Buonocore, Paola Gabanelli, Marina Rita Manera, Antonia Pierobon
• Format: Journal Article
• Language: English
• Published: Public Library of Science (PLoS) 01.01.2024
• ISSN: 1932-6203
• DOI: 10.1371/journal.pone.0306256

BackgroundThe heightened risk of dementia resulting from multiple comorbid conditions calls for innovative strategies. Engaging in physical and cognitive activities emerges as a protective measure against cognitive decline. This protocol aims to discuss a multidomain intervention targeting individuals with dementias secondary to cerebrovascular or other medical diseases, emphasizing an often underrepresented demographic.MethodsThis study primary objectives are: a) to identify patients affected by Neurocognitive disorder due to vascular disease or multiple etiologies (screening and diagnostic phase) and b) to evaluate the effectiveness of distinct rehabilitation protocols (intervention phase): motor training alone, paper-based cognitive rehabilitation combined with motor training, digital-based cognitive rehabilitation coupled with motor training.DiscussionIdentifying cognitive impairment beyond rigid neurological contexts can facilitate timely and targeted interventions. This protocol strives to address the complex interplay of cognitive decline and comorbidities through a multidimensional approach, providing insights that can shape future interventions and enhancing overall well-being in this vulnerable population.Trial registrationThe study has been registered on July 13, 2023 with the ClinicalTrials.gov NCT05954741 registration number (https://classic.clinicaltrials.gov/ct2/show/NCT05954741).