Construction and Validation of a Screening Model for Early Atherosclerosis Risk in the Aorta

• Published in: Zhongguo quanke yixue Vol. 27; no. 33; pp. 4147 - 4154
• Main Author: ZHOU Zhensen, HUANG Yan, CHENG Siwei, ZHANG Xiaoyu, ZHANG Xiaoyu, SUN Ting, YANG Xianjun, XIE Hui, MA Zuchang
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01.11.2024
• Subjects: arteriosclerosis|aortic stiffness|carotid-femoral pulse wave velocity|prediction model|early screening
• ISSN: 1007-9572
• DOI: 10.12114/j.issn.1007-9572.2024.0032

Background In the field of cardiovascular risk assessment, aortic stiffness is considered a key predictive indicator, and carotid-femoral pulse wave velocity (cfPWV) is recognized as the gold standard for non-invasive assessment of atherosclerotic risk in the aorta. Due to challenges such as technical difficulty, cfPWV testing has not been widely implemented in China. Objective This study aimed to develop and validate a screening model for early atherosclerotic risk in the aorta based on cardiovascular risk factors, with the intention of replacing the complex measurement process of cfPWV and reducing reliance on traditional measurement methods. Methods A total of 878 participants recruited from the Health Checkup Center of the First Affiliated Hospital of Anhui Medical University between May and November 2023 were selected as research subjects, randomly divided into a model-building group (n=703) and a validation group (n=175) in an 8∶2 ratio. Patient general information, laboratory test results, and cfPWV we