Effect of Wuzhuyu Decoction on alcoholic gastric ulcer and its mechanism

• Published in: 精准医学杂志 Vol. 40; no. 4; pp. 309 - 316
• Main Author: GAO Ruiyang, LI Jingyao, LI Pingxiang, GE Keli
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of Precision Medicine 01.08.2025
• Subjects: stomach ulcer|wuzhuyu decoction|qxidative stress|phosphatidylinositol 3-kinases|proto-oncogene proteins c-akt|nf-kappa b|signal transduction
• ISSN: 2096-529X
• DOI: 10.13362/j.jpmed.202540075

Objective To investigate the effect of Wuzhuyu Decoction (WZYD) on alcoholic gastric ulcer and its mechanism. Methods A total of 120 female KM mice, aged 8 weeks, were randomly divided into normal control group (group A), model control group (group B), ranitidine group (group C), and low-, middle-, and high-dose WZYD groups (groups D-F), with 20 mice in each group. The mice in groups A and B were given distilled water (10 mL/kg) at room temperature by gavage, those in group C were given ranitidine (30 mg/kg) by gavage, and those in groups D-F were given WZYD by gavage at a dose of 5, 10, and 20 mL/kg, respectively. After 7 consecutive days of intragastric administration, 10 mice were selected from each group, and serum was collected under aseptic conditions for cell experiments, and the remaining mice were still given distilled water or the drug by gavage for another 21 days. Body weight and food intake of the mice in each group were recorded on days 7, 14, 21, and 28. On day 29, serum, gastric juice, and gas