Association between Triglyceride-glucose Index and Its Derivatives Index and the Development of Type 2 Diabetes: a Nested Case-control Study

• Published in: Zhongguo quanke yixue Vol. 26; no. 12; pp. 1456 - 1462
• Main Author: GE Xuhong, HU Jieyi, BAI Yunrui, WANG Lu, LENG Song
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01.04.2023
• Subjects: diabetes mellitus, type 2|tyg|tyg-bmi|case-control studies|nested case-control study|restrictive cubic splines
• ISSN: 1007-9572
• DOI: 10.12114/j.issn.1007-9572.2022.0737

Background China has the largest number of diabetic patients in the world. Insulin resistance is a major pathogenetic mechanism and cause of type 2 diabetes. Recent studies have suggested potential relationship between triglyceride-glucose index (TyG) and its derivatives index and the development of type 2 diabetes. However, most available evidence is from cross-sectional study or longitudinal study, and there is a lack of studies in the northeast China. Objective To explore the association between TyG and its derivatives index called triglyceride glucose-body mass index (TyG-BMI) and the incidence risk of type 2 diabetes, analyze the predictive capacity of TyG and TyG-BMI for type 2 diabetes, so as to provide a scientific basis for the early screening of high risk population with type 2 diabetes. Methods A total of 6843 cases of physical examination in the health management center of the Second Affiliated Hospital of Dalian Medical University from January 2015 to December 2017 were included as research subje