IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS

The study was devoted to development of non-invasive methods for diagnosis of liver fibrosis in patients with chronic viral hepatitis (CVH). The stepwise logistic multivariate regression analysis of biochemical (PTI, glucose, albumin, AST, LDH) and immunological parameters (the functional activity o...

Full description

Saved in:
Bibliographic Details
Published inActa biomedica scientifica no. 3(2); pp. 231 - 236
Main Authors M. V. Shipunov, N. M. Starostina, E. L. Gelfgadt, E. R. Chernykh, A. A. Ostanin
Format Journal Article
LanguageRussian
Published Scientific Сentre for Family Health and Human Reproduction Problems 01.05.2012
Subjects
chronic virus hepatitis
fibrosis stages
non-invasive diagnostics
Online AccessGet full text

Cover

More Information
Summary:The study was devoted to development of non-invasive methods for diagnosis of liver fibrosis in patients with chronic viral hepatitis (CVH). The stepwise logistic multivariate regression analysis of biochemical (PTI, glucose, albumin, AST, LDH) and immunological parameters (the functional activity of neutrophils and monocytes, the relative content of CD8+ T- and CD19+B-cells) was used for the establishment of diagnostic model. Based on the multiple regression analysis we derived a 2 novel Integral Indexes of Liver Fibrosis (IILF-biochem and IILF-immun, respectively). It is shown that IILF-biochem allows, without resorting to liver biopsy to predict the appropriate stage of fibrosis in CHV patients with diagnostic accuracy of 86—87 %, and in combination with IILF — at 97.7 %.
ISSN:2541-9420
2587-9596