Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection

Here, we report the label-free, sensitive, and real-time electrical detection of whole viruses using carbon nanotube thin film (CNT-TF) field effect devices. Selective detection of approximately 550 model viruses, M13-bacteriophage, is demonstrated using a simple two-terminal (no gate electrode) con...

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Bibliographic Details
Published inTheranostics Vol. 2; no. 1; pp. 251 - 257
Main Author Himadri S. Mandal, Zhengding Su, Andrew Ward, Xiaowu (Shirley) Tang
Format Journal Article
LanguageEnglish
Published Ivyspring International Publisher 01.01.2012
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Summary:Here, we report the label-free, sensitive, and real-time electrical detection of whole viruses using carbon nanotube thin film (CNT-TF) field effect devices. Selective detection of approximately 550 model viruses, M13-bacteriophage, is demonstrated using a simple two-terminal (no gate electrode) configuration. Chemical gating through specific antibody-virus binding on CNT surface is proposed to be the sensing mechanism. Compared to electrical impedance sensors with identical microelectrode dimensions (no CNT), the CNT-TF sensors exhibit sensitivity 5 orders higher. We believe the reported approach could lead to a reproducible and cost-effective solution for rapid viral identification.
ISSN:1838-7640
1838-7640