A Case Report of Dublin-Johnson Syndrome

Hyperbilirubinemia is a common manifestation in internal medicine. It is divided to conjugated and unconjugated hyperbilirubinemia . Conjugated hyperbilirubinemia usually results from hepatocellular or cholestatic liver disease or from extrahepatic biliary obstruction. Isolated conjugated hyperbilir...

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Bibliographic Details
Published inPizishkī-i bālīnī-i Ibn-i Sīnā Vol. 6; no. 4
Main Author Amir Hooshang Mohammad Alizadeh
Format Journal Article
LanguagePersian
Published Hamadan University of Medical Sciences 01.03.2000
Subjects
chronic idiopathic
hyperbilirubinemia / jaundice
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Summary:Hyperbilirubinemia is a common manifestation in internal medicine. It is divided to conjugated and unconjugated hyperbilirubinemia . Conjugated hyperbilirubinemia usually results from hepatocellular or cholestatic liver disease or from extrahepatic biliary obstruction. Isolated conjugated hyperbilirubinemia is the primary manifestation of two heritable disorders, Rotor and Dublin – Johnson syndromes, and can also be seen in some patients with the syndrome of recurrent benign intrahepatic cholestasis. Dubin – Johnson syndrome is a rare, benign autosmally inheritd hyperbilirubinemia characterized by presence of dark pigment in the centrilobular regin of the liver cells. Patients with Dubin – Johnson syndrome may be asymptomatic or have vague constitational or gasterointestinal syndromes. Pruritus is absent, and serum bile acid levels are normal.
ISSN:2588-722X
2588-7238