Fridel-Crafts alkylation of iodine catalyed by ultrasound assisted

Triarymethanes (TRAMs) are used as antitubercular agents, antitumor or antiviral.1 Was weighed 2 mmol of (1a), 1 mmol of (2a), 10 mol% of I2 in 5 mL of CH2Cl2, the reaction was brought to ultrasound bath (SONIC MODEL LS-4, 7D) of 44 kH and 150 W (Scheme 1).The product was purified on silica gel-60,...

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Published inOrbital : The Electronic Journal of Chemistry Vol. 4; no. 1; pp. 100 - 101
Main Authors Manoel G. de Oliveira, Deluana M. Neto, Tairine Pimentel, Brenda G. Sturnich, Thaísa K. A. Fagundes, Irlon M. Ferreira, Sandro Minguzzi
Format Journal Article
LanguageEnglish
Published Universidade Federal de Mato Grosso do Sul 01.06.2012
Subjects
alkylation
iodine
ultrasound
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Summary:Triarymethanes (TRAMs) are used as antitubercular agents, antitumor or antiviral.1 Was weighed 2 mmol of (1a), 1 mmol of (2a), 10 mol% of I2 in 5 mL of CH2Cl2, the reaction was brought to ultrasound bath (SONIC MODEL LS-4, 7D) of 44 kH and 150 W (Scheme 1).The product was purified on silica gel-60, eluting mixture 8:2 of (Hexano:Ethyl acetate). Under these conditions 65% of the product (3a) was obtained. The compound was characterized by third m.p. 161ºC (161-162ºC).1 The Fridel-Crafts alkylation catalyzed by I2 bath ultrasound occurs at short reaction time requiring less energy expenditure compared to the method of agitation. It is intended to increase the study of various aromatic compounds (1), different aldehydes (2) and vary the use of solvents.
ISSN:1984-6428
DOI:10.17807/orbital.v4i1.389