Ferroptosis: a New Target for the Treatment of Depressive Disorder

As a common affective mental disorder, depressive disorder has currently become the second health burden worldwide, however, its pathogenesis remains to be further elucidated. The clinical treatment of depressive disorder primarily relies on western medicine. However, there is great clinical need fo...

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Published inZhongguo quanke yixue Vol. 27; no. 12; pp. 1417 - 1423
Main Author DU Shuqin, QIAN Lifeng, XIONG Lie, SHI Hanqiang, SHI Yanbo
Format Journal Article
LanguageChinese
Published Chinese General Practice Publishing House Co., Ltd 01.04.2024
Subjects
depressive disorder|ferroptosis|iron overload|mitochondria|lipid peroxidation|review
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Summary:As a common affective mental disorder, depressive disorder has currently become the second health burden worldwide, however, its pathogenesis remains to be further elucidated. The clinical treatment of depressive disorder primarily relies on western medicine. However, there is great clinical need for effective and rapid-onset antidepressants for the unsatisfactory effect, obvious treatment time-lag, and intolerable adverse reactions of current drug treatment. Ferroptosis is a novel form of cell death discovered in recent years, which has been found to be involved in the pathogenesis of numerous neurological disorders, including depressive disorder. Currently, some studies have shifted the focus of antidepressant treatment towards targeted inhibition of ferroptosis, and achieved positive outcomes. The present paper provides a comprehensive review of the involvement of ferroptosis in depressive disorder pathogenesis and its potential therapeutic implications, drawing on clinical and preclinical evidence that el
ISSN:1007-9572
DOI:10.12114/j.issn.1007-9572.2023.0228