CHANGES PROTEIN SPECTRUM OF BLOOD PLASMA, WHICH DEVELOP IN PATIENTS WITH CHRONIC HEPATITIS C AFTER AUTOHAEMOTHERAPY

Purpose: to study in patients with chronic hepatitis C the pathogenesis hematopoietic activities of autologous blood hemolysate.Materials and methods: we made an indirect MALD-TOF-mass spectrometry of blood plasma in 37 patients with chronic hepatitis C who received the autologous blood hemolysate....

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Published inMedicinskij vestnik Ûga Rossii no. 4; pp. 39 - 44
Main Authors D. V. Dontcov, E. F. Shin, Yu. M. Ambalov, S. V. Mordanov
Format Journal Article
LanguageEnglish
Published State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation 01.12.2015
Subjects
chronic hepatitis c antiviral therapy
hematologic complications
hemolysis
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Summary:Purpose: to study in patients with chronic hepatitis C the pathogenesis hematopoietic activities of autologous blood hemolysate.Materials and methods: we made an indirect MALD-TOF-mass spectrometry of blood plasma in 37 patients with chronic hepatitis C who received the autologous blood hemolysate. The study was performed twice: before autohemotherapy and after 10 days of daily intravenous injections of 20.0 ml of the autologous blood hemolysate.Results: succeeded in isolating a blood plasma over 300 polypeptide sequence. Thus, as a result of intravenous administration of 20.0 ml autologous blood hemolysate frequency of IL-1β, IL-3, IL-6, IL-9, IL-11 and erythroferron significantly increased and the IL-10 and IL-13, by contrast, dropped .Summary: identification of proteomic changes in the profile of blood plasma in the predominance of proteins that stimulate hematopoiesis probably accounts for the clinical effectiveness of the autologous blood hemolysate.
ISSN:2219-8075
2618-7876
DOI:10.21886/2219-8075-2015-4-39-44