ABOUT THE OPPORTUNITIES TO Influence MICROORGANISMS ON THE IRON HOMEOSTASIS IN THE HOST ORGANISM (Literature review)

Iron homeostasis, aimed at depriving the pathogen of available iron, takes an important role in protecting human body against pathogens. When infection occurs, microorganisms must overcome iron deficiency in a host organism. This review describes microorganisms' ways of gaining iron in the host...

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Published inActa biomedica scientifica no. 1; pp. 120 - 124
Main Authors V. V. Leonov, N. A. Kurlovich, L. V. Leonova, N. M. Fateeva
Format Journal Article
LanguageRussian
Published Scientific Сentre for Family Health and Human Reproduction Problems 01.02.2014
Subjects
antihepcidin activity
hepcidin
iron homeostasis
microorganisms’ ways of gaining iron
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Summary:Iron homeostasis, aimed at depriving the pathogen of available iron, takes an important role in protecting human body against pathogens. When infection occurs, microorganisms must overcome iron deficiency in a host organism. This review describes microorganisms' ways of gaining iron in the host organism, presents present-day data on changing of iron homeostasis during infection and the main regulators of this process. Theoretical substantiation was given of the possibility of microorganisms' influence on iron homeostasis due to ability to inactivate hepcidin - antihepcidin activity.
ISSN:2541-9420
2587-9596