The therapeutic targets and clinical translational research in vitiligo

Vitiligo is a chronic autoimmune disease characterized by depigmentation of the skin, significantly impacting patients' quality of life. Recent advances in immunological and molecular biological studies have identified numerous potential therapeutic targets for vitiligo, paving the way for nove...

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Bibliographic Details
Published in生物医学转化 Vol. 5; no. 2; pp. 111 - 115
Main Authors Zhao Liuqi, Zou Jing, Shen Qingqing, Tong Linhui, Yang Qing, Zhang Yuehuang, Wang Honglin
Format Journal Article
LanguageChinese
Published Lanzhou University Press 01.06.2024
Subjects
clinical translation
jak inhibitors
pde-4 inhibitors
therapeutic targets
vitiligo
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Summary:Vitiligo is a chronic autoimmune disease characterized by depigmentation of the skin, significantly impacting patients' quality of life. Recent advances in immunological and molecular biological studies have identified numerous potential therapeutic targets for vitiligo, paving the way for novel treatment strategies. This article reviews the advancements in researching novel immunotherapy targets such as the JAK/ STAT pathway, PDE-4, Wnt/β-catenin pathway, and IL-15, along with their respective targeted drugs. The article aims to provide insights into the clinical translation of future therapeutic targets for vitiligo.
ISSN:2096-8965
DOI:10.12287/j.issn.2096-8965.20240213