Malignant Retroperitoneal Paraganglioma with T11 Metastasis and Compression of the Spinal Cord

A 38 years old male worker presented with an advanced left side retroperitoneal mass, with metastatic involvement of 11th Thoracic Vertebra (T11) and resultant paraparesia and paresthesia . The histopathologic examination and immunohistochemical analysis confirmed the diagnosis of paraganglioma. Dec...

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Published inBasic and clinical cancer research Vol. 6; no. 4
Main Authors Habibollah Mahmoodzade, Abdolreza Sheikhrezai, farhad Samiei, Afsaneh Alikhassi, Fazel Elahi, Fereshteh Ensani, Afshin Abdi-e-rad, Sina Izadyar, Ramesh Omranipur, Mohammad Reza Mir, Zahra Sedighi, Siamak Shariat-e-torbaghan, Mohammad-Ali Mohagheghi
Format Journal Article
LanguageEnglish
Published Tehran University of Medical Sciences 01.12.2014
Subjects
I-MIBG therapy
Metastasis
Retroperitoneal paraganglioma
Spinal cord
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Summary:A 38 years old male worker presented with an advanced left side retroperitoneal mass, with metastatic involvement of 11th Thoracic Vertebra (T11) and resultant paraparesia and paresthesia . The histopathologic examination and immunohistochemical analysis confirmed the diagnosis of paraganglioma. Decompression laminectomy and fixation of involved vertebra resulted to considerable symptomatic relief. Due to unresectability at presentation, chemotherapy with palliative intent performed, and resulted to mild response.  Palliative debulking performed after chemotherapy and resulted to better quality of patient's life during next 8 months. Remaining  mass at pelvic area increased in size and patient received    (131)I-MIBG therapy, 8 months post-operatively. A second debulking surgery, as well as other palliative measures will be considered for future.
ISSN:2228-6527
2228-5466