Glymphatic System: a New Research Direction for the Pathogenesis of Brain Diseases

The glymphatic system is mainly mediated by aquaporin 4 on astrocytes and relies on the exchange and flow of cerebrospinal fluid and brain tissue fluid in the vascular space around arteries and veins. It is a common feature of encephalopathy such as Alzheimer's disease, stroke, Parkinson's...

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Bibliographic Details
Published inZhongguo quanke yixue Vol. 25; no. 29; pp. 3603 - 3606
Main Author Zeran CHEN, Ting YI, Ping GAO, Shuoguo JIN
Format Journal Article
LanguageChinese
Published Chinese General Practice Publishing House Co., Ltd 01.10.2022
Subjects
glymphatic system|brain diseases|brain perivascular spaces|aquaporin 4
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Summary:The glymphatic system is mainly mediated by aquaporin 4 on astrocytes and relies on the exchange and flow of cerebrospinal fluid and brain tissue fluid in the vascular space around arteries and veins. It is a common feature of encephalopathy such as Alzheimer's disease, stroke, Parkinson's disease, insomnia, depression. It is a new brain metabolic pathway that can remove metabolites including β-amyloid and lactate. This paper comprehensively analyzes the global research on the glial lymphatic system in brain diseases, and concludes that the glial lymphatic system may bring a new perspective for the study of the pathogenesis and diagnosis and treatment strategies of neurodegenerative diseases; glial lymphatic system is expected to provide new and effective evidence for the diagnosis of some brain diseases; the glial lymphatic system may be a new way to treat brain diseases.
ISSN:1007-9572
DOI:10.12114/j.issn.1007-9572.2022.0326