Phenobarbital influence on neuromuscular block produced by rocuronium in rats Influência do fenobarbital no bloqueio neuromuscular produzido pelo rocurônio em ratos

• Published in: Acta cirúrgica brasileira Vol. 23; no. 4; pp. 343 - 347
• Main Authors: Angélica de Fátima de Assunção Braga, Caroline Coutinho de Barcelos, Franklin Sarmento da Silva Braga, Samanta Cristina Antoniassi Fernandes, Yoko Oshima Franco, Mario Mantovani, Léa Rodrigues Simioni
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01.08.2008
• Subjects: Bloqueadores Neuromusculares; Fenobarbital; Neuromuscular Blocking Agents; Phenobarbital; Ratos; Rats

PURPOSE: To evaluate in vitro and in vivo neuromuscular blockade produced by rocuronium in rats treated with Phenobarbital and to determine cytochrome P450 and cytochrome b5 concentrations in hepatic microsomes. METHODS: Thirty rats were included in the study and distributed into 6 groups of 5 anima...