Prenatal Invasive Diagnosis with Quantitative Fluorescent PCR

Purpose: To develop the method of prenatal invasive diagnosis and compare it abilities with traditional genetic cytological examination.Materials and Methods: There was conducted prenatal fetal invasive diagnosis of 366 pregnant women. Depending on the pregnancy age and genetic indications the chori...

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Bibliographic Details
Published inMedicinskij vestnik Ûga Rossii no. 2; pp. 60 - 62
Main Authors V. V. Avrutskaja, N. V. Kriventsova, R. A. Shokarev, V. S. Gimbut, S. Y. Kriger
Format Journal Article
LanguageEnglish
Published State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation 01.06.2011
Subjects
chromosome diseases
prenatal diagnosis
quantitative polymerase-chain reaction
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Summary:Purpose: To develop the method of prenatal invasive diagnosis and compare it abilities with traditional genetic cytological examination.Materials and Methods: There was conducted prenatal fetal invasive diagnosis of 366 pregnant women. Depending on the pregnancy age and genetic indications the chorionic villus sampling, cordocentesis and amniocentesis were carried.Results: The obtained samples was treated with QF-PCR and it results was verified by standard karyotyping. In all cases, the differences of the two methods was not observed.Summary: It was shown the technique of quantitative fluorescent polymerase chain reaction (QF-PCR) has advantages over the standard cytologic examination and reduces analysis duration and increases the number of patients.
ISSN:2219-8075
2618-7876