New opportunities for the use of alpha-lipoic acid: the role of enantiomers

The literature review considers the use of alpha-li­poic acid (ALA) in clinical practice. The positive effects of ALA as an antioxidant have been demonstrated for a wide range of diseases: diabetic neuropathy, atherosclerosis, hepatitis, cerebrovascular disorder, etc. The new data on the application...

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Published inMiz︠h︡narodnyĭ endokrynolohichnyĭ z︠h︡urnal Vol. 15; no. 6; pp. 507 - 514
Main Authors T.Yu. Yuzvenko, S.A. Tarasenko, O.V. Marchenko
Format Journal Article
LanguageEnglish
Published Zaslavsky O.Yu 01.09.2019
Subjects
alpha-lipoic acid
enantiomers
review
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Summary:The literature review considers the use of alpha-li­poic acid (ALA) in clinical practice. The positive effects of ALA as an antioxidant have been demonstrated for a wide range of diseases: diabetic neuropathy, atherosclerosis, hepatitis, cerebrovascular disorder, etc. The new data on the application of the R(+) enantiomer ALA has proved positive biological effects of ALA using. The only R(+) enantiomer ALA realizes all ALA positive features. The R(+) enantiomers of alpha-lipoic acid have the highest peak of plasma concentrations and AUC compared with racemic mixtures. It was showed that 300 mg of R(+) enantiomer of ALA is bioequivalent to 600 mg of racemic ALA.
ISSN:2224-0721
2307-1427
DOI:10.22141/2224-0721.15.6.2019.185414