Effect of KTP Laser Made byAEOI on Resected Prostateafter Open Prostatectomy

• Published in: Armaghān-i dānish Vol. 13; no. 2; pp. 11 - 18
• Main Authors: MR Razzaghi, M Mohammad hosseini, AR Rezaei, I Rezaei, S.H Nicknam, B Javanmard
• Format: Journal Article
• Language: Persian
• Published: Yasuj University Of Medical Sciences 01.07.2008
• Subjects: Benign Prostatic Hyperplasia (BPH)
• ISSN: 1728-6506; 1728-6514

Introduction & Objective: Transurethral resection of prostate (TURP) is the operation most frequently performed in urology. In view of the morbidity associated with this procedure, research has been conducted to propose an endoscopic alternative to TURP. Using of high energy laser is the most promising method in these cases. In this study, we evaluated the effect of home made KTP laser on re-sected prostate adenoma after open prostatectomy. Materials & Methods: 40 patients complaining of symptomatic BPH were treated by open prostatectomy. These 40 prostates were divided in to two parts. One part was sent for pathology assessment (group A) and the other part was sent to KTP laser room in the same hospital (group B). The prostates in group B were divided into 4 groups (1, 2, 3, 4), each with 10 prostate tissue. In groups 1, 2, 3 and 4, prostate lobes underwent laser ablation in one, two three and four stage. In any stage, KTP laser, 5 watts for 15 seconds, was used. All of prostate ablated with laser were sent to pathology for evaluation of tissue ablation capacity and deep tissue penetration. The study in all of stages was blinded for pathologist. Results: Mean age of participants was 73.25±6.8 years and mean level of PSA was 3.65±2.1 ng/dl. In both groups, with every stage laser, we have 1 to 2 mm tissue ablation associated with prostate type. In pathologic examination, we have 0-2 mm tissue destruction with disappearance of cells' nuclei, basophilia of stroma and damaged tissue (cutter like effect). Findings were compatible with burn effect. Conclusion: Pathologic findings proved, in the ex vivo investigation, that KTP laser offers a good tissue ablation capacity and minimal microscopic tissue damage. The risk of capsule perforation is very low. This procedure is safe and effective in which bladder outlet obstruction symptoms will be quickly relieves and has a low rate of complications. Moreover KTP laser has much cost effectiveness, although we need further studies on live prostatic tissues