Association of genetic variant rs3662C＞A in the gene of p21-activated kinase 2 with risk and prognosis of stroke as well as its effect on transcription activity

• Published in: Ji chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics Vol. 41; no. 4; pp. 472 - 478
• Main Author: SI Bin, ZHANG Shu-yuan, YANG Yun-yun, CHEN Yu, ZHANG Wei-li
• Format: Journal Article
• Language: Chinese
• Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College 01.04.2021
• Subjects: p21-activated kinase 2(pak2)|genetic variants|susceptibility|stroke|prognosis
• ISSN: 1001-6325

Objective To identify the relationship between variant rs3662C＞A in the gene of p21-activated kinase 2 (PAK2) and risk of stroke as well as prognosis, and to explore the effect of rs3662C＞A on the transcriptional activity of PAK2 gene. Methods In a multi-center case-control study including 733 cerebral atherothrombotic stroke, 488 lacunar infarction, 435 intracerebral hemorrhage and 1 727 healthy controls, the relationship between variant and risk of three stroke subtypes was examined using the multivariate logistic regression model. The stroke patients were prospectively followed up for a median of 4.5 years, and the relationship between rs3662 and cardiovascular events as well as mortality was analyzed using the Cox proportional-hazards model. The effect of rs3662C＞A on the transcriptional activity of PAK2 gene was examined using the luciferase reporter assays. Results The rs3662A allele was associated with a decreased risk of atherosclerotic stroke as compared with rs3662CC genotype, and odds ratio was 0.6