Bacterial infections in pediatric and adolescent in allogeneic hematopoietic stem cell transplantation recipients: etiology, structure, risk factors

• Published in: Zhurnal infektologii Vol. 5; no. 1; pp. 35 - 43
• Main Authors: M. Yu. Averyanova, V. N. Vavilov, S. N. Bondarenko, O. S. Uspenskaya, N. V. Stancheva, E. V. Semenova, A. G. Volkova, B. I. Smirnov, I. B. Baranova, L. S. Zubarovskaya, N. N. Klimko, B. V. Afanasyev
• Format: Journal Article
• Language: Russian
• Published: Journal Infectology 01.09.2014
• Subjects: бактериальные инфекции; трансплантация аллогенных гемопоэтических стволовых клеток; факторы риска
• ISSN: 2072-6732; 2499-9865
• DOI: 10.22625/2072-6732-2013-5-1-35-43

155 children and adolescents who had been diagnosed oncohematological diseases and had undergone allogeneic hemapoetic stem cell transplantation were examined. In post-transplant period 80% of patients developed different bacterial complications. Main risk factors of bacterial infections were acute leukemia (73%), acute «graft versus host disease» (61%), severe infectious complications before HSCT (30%), cytomegaloviral reactivation (51%). Main causative agents were Kl. pneumoniae (15%), Escherichia coli (8%), Enterobacter sp. (7%), Pseudomonas sp. (6,5%), Enterococcus sp. (16,5%), S.еpidermidis (13,5%). Most frequent involved sites are urinary tract (30,6%), lungs (22,5%) and bacteriemia (38,7%). Rise in ciprofloxacin resistans among Entorobactri, aerobic and Gram-positive cocci. General survival rate of patients with bacterial complications was 36,3% (p<0,001). Number of infectious episodes and their severity were statistically significant (both p<0,001) deteriorating factor for general surviral rate.