Protective effects of sterofundin on myocardial injury in septic rats

Objective To investigate the protective effects of sterofundin on myocardial injury in septic rats. Methods A total of 280 SPF SD rats (half male and female, 12~14 weeks old, 200~220 g) were randomly divided into 4 groups: sham operation (Sham) group, sepsis (Sep) group, conventional treatment (Ct)...

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Published inLu jun jun yi da xue xue bao Vol. 44; no. 20; pp. 2054 - 2060
Main Authors TAN Lei, SHE Han, GUO Ningke
Format Journal Article
LanguageChinese
Published Editorial Office of Journal of Army Medical University 01.10.2022
Subjects
myocardial injury
sepsis
sodium malate
sterofundin
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Summary:Objective To investigate the protective effects of sterofundin on myocardial injury in septic rats. Methods A total of 280 SPF SD rats (half male and female, 12~14 weeks old, 200~220 g) were randomly divided into 4 groups: sham operation (Sham) group, sepsis (Sep) group, conventional treatment (Ct) group (with Ringer's lactate solution+dopamine+cefuroxime sodium), and malate ringer's solution (Mr) group (with sterofundin+dopamine+cefuroxime sodium). The rat model of sepsis was inflicted by cecal ligation and puncture (CLP). Subsequently, the effects of sterofundin treatment on the myocardial injury, cardiac output (CO), oxygen supply and consumption, liver and kidney perfusion, liver and kidney functions, survival time and survival rate of septic rats were observed. Results The cardiac output (CO), cardiac index (CI) and stroke index (SI) were significantly decreased in the Sep group, while the injuries were improved to some extent in the Ct group (P < 0.05). As compared with the Sep group, the improvement wa
ISSN:2097-0927
DOI:10.16016/j.2097-0927.202205039