Significance of Th1/Th2 cytokine spectrum in differential diagnosis and prognostic prediction of G-/G+ bacterial sepsis

• Published in: Xīn yīxué Vol. 54; no. 4; pp. 277 - 281
• Main Author: Zeng Sufen, Xie Guojin, Zhang Suzhen, Zhou Yong
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of New Medicine 01.04.2023
• Subjects: sepsis|cell infection|t helper lymphocyte|interleukin-6|interleukin-10|interferon-γ|differential diagnosis|prognosis
• ISSN: 0253-9802
• DOI: 10.3969/j.issn.0253-9802.2023.04.009

Objective To study the significance of Th1/Th2 cytokine spectrum in the differential diagnosis and prognostic prediction of Gram-negative/Gram-positive bacterial sepsis. Methods Clinical data of 120 patients with sepsis were collected. According to the bacterial culture results， all patients were divided into the Gram-negative infection （G- group， n=65） and Gram-positive groups （G+ group， n=55）. Based on the 28 d follow-up outcomes， all patients were assigned into the death （n=41） and survival groups （n=79）. The Th1/Th2 cytokine profile including interleukin （IL）-2， IL-4， IL-6， IL-10， interferon （IFN）-γ and TNF-α was compared between the G- and G+ groups， and between the death and survival groups， respectively. The significance of combined detection of IL-6， IL-10 and IFN-γ in the differential diagnosis and prognostic assessment of G-/G+ was evaluated. Results There were no significant differences in IL-2， IL-4 and TNF-α levels between G- and G+ groups （all P > 0.05）， whereas IL-6，IL-10 and IFN-γ levels in th