The potential of excipients to improve the efficiency of immuno-oncology therapy
The cocktail of substances used in cell culture media to cryopreserve, transfect, grow, expand, fractionate, concentrate, wash and remove impurities from leukapheresis harvested T-cells are functional excipients. Even though most of them are not present in the final product, they nonetheless have th...
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| Published in | Journal of excipients and food chemicals |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
International Pharmaceutical Excipients Council
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| Online Access | Get full text |
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| Summary: | The cocktail of substances used in cell culture media to cryopreserve, transfect, grow, expand, fractionate, concentrate, wash and remove impurities from leukapheresis harvested T-cells are functional excipients. Even though most of them are not present in the final product, they nonetheless have the potential – during in vitro manufacture - to determine the subsequent in vivo proliferative capacity, persistance, safety and compositional phenotype of the injected re-engineered T-cells. Thus, while the chimeric antigen receptor and co-stimulatory signaling molecules are necessary for CAR-T cell functionality, they may not be sufficient to achieve this functionality unless manufactured using the right cocktail of functional excipients. |
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| ISSN: | 2150-2668 |