Role of endothelial dysfunction in pathogenesis of atherosclerosis

Accoding to modern views, endothelial dysfunction is considered to be the key link in pathogenesis of atherosclerosis, manifesting in imbalance between endothelial vasoactive substances – vasodilators and vasoconstrictors. Is demonstrated, that practically all risk factors of atherosclerosis realise...

Full description

Saved in:
Bibliographic Details
Published inAteroskleroz Vol. 7; no. 1; pp. 60 - 69
Main Authors Yu. P. Nikitin, G. I. Simonova, M. A. Khoreva, R. I. Vorobiov, E. N. Vorobiova, G. I. Shumaher, I. V. Osipova, I. B. Kyperman
Format Journal Article
LanguageRussian
Published Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics 01.06.2011
Subjects
atherosclerosis
endothelial dysfunction
nitric oxide
risk factors
Online AccessGet full text

Cover

More Information
Summary:Accoding to modern views, endothelial dysfunction is considered to be the key link in pathogenesis of atherosclerosis, manifesting in imbalance between endothelial vasoactive substances – vasodilators and vasoconstrictors. Is demonstrated, that practically all risk factors of atherosclerosis realises the unfavorable effect through endothelial dysfunction. In this connection, is actual to asses the indexes of endothelial function in men with risk factors of atherosclerosis as the markers of early atherosclerotic changes of vessels. The assigning of pathogenetic therapy at this stage, and also for faces with the demonstrated atherosclerosis will allow considerably improve the prognosis of patients.
ISSN:2078-256X