Immunoglobulin is valuable in the differential diagnosis of primary biliary cholangitis, hepatitis E and cirrhosis

• Published in: Ji chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics Vol. 43; no. 8; pp. 1271 - 1274
• Main Author: XING Xuemei, YANG Jianrui, LI Zhijun, CHEN Yajuan, YAO Fengxia, LIU Zheng
• Format: Journal Article
• Language: Chinese
• Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College 01.08.2023
• Subjects: hepatitis e|primary biliary cholangitis|cirrhosis|igg|igm
• ISSN: 1001-6325
• DOI: 10.16352/j.issn.1001-6325.2023.08.1271

Objective To explore the value of immunoglobulin in differential diagnosis of primary biliary cholangitis (PBC), hepatitis E and liver cirrhosis. Methods Blood samples were collected from 121 patients with PBC and 107 healthy people. The serum r-glutamyltransferase (r-GT), alkaline phosphatase (ALP), immunoglobulin IgG and IgM, total cholesterol (TCH) and lipoprotein (a)[Lp(a)] were detected by biochemical routine tests; Blood routine counted white blood cells (WBC) and platelets (PC); The IgG and IgM antibodies of HEV were detected by enzyme-linked immunosorbent assay (ELISA). Results r-GT, ALP, IgG and IgM in PBC patients increased significantly (P＜0.05) accompanied by significant decrease in WBC and PC values (P＜0.05). In patients with PBC cirrhosis, IgG increased significantly (P＜0.05), while WBC and PC values decreased significantly(P＜0.05). IgG and IgM in patients with PBC+cirrhosis+HEV antibody positive increased significantly(P＜0.05), while WBC and PC values decreased significantly (P＜0.05). Conclusio