Study on D-dimer elevation in patients with colorectal cancer

• Published in: Waike Lilun yu Shijian Vol. 26; no. 4; pp. 361 - 366
• Main Author: MAO Jieqi, XU Duogang, ZHANG Mili, XIAO Yunyu, MING Xu, LI Yuzhe, CAO Can, YU Liang, LI Jikun
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of Surgery Concepts & Practice 01.07.2021
• Subjects: colorectal cancer|thromboembolism|venous thrombosis|metastasis|d-dimer
• ISSN: 1007-9610
• DOI: 10.16139/j.1007-9610.2021.04.015

Objective To analyze the association of coagulation with clinical parameters in patients with colorectal cancer. Methods Clinical and pathological data in the patients with colorectal cancer and surgical treatment were collec-ted from August 2018 to December 2019 in the Department of Gastrointestinal Surgery in our hospital. Retrospective analysis was performed to study the related factors to hypercoagulability with preoperative D-dimer value as index. Results A total of 104 from 249 (41.8%) cases exhibited elevated D-dimer (>550 μg/ L) in serum preoperatively. Twenty-seven (10.8%) cases had a significant elevation of D-dimer(>1 650 μg/ L) three times higher than normal limit. There were 7 cases with venous thromboembolism(VTE) postoperatively. Multivariate analysis showed that the preoperative elevated D-dimer in serum was associated with far metastasis and intraluminal invasion. Elevated D-dimer was found 73.3% cases with metastasis and 37.6% cases without metastasis(P<0.01), and 51.9% cases with intralumin