Changes of plasma sonic hedgehog and its clinical significance in chronic kidney disease stage 3-5

ObjectiveTo examine the changes of plasma levels of sonic hedgehog （SHH） in patients with chronic kidney disease （CKD） stage 3-5 and explore the clinical characteristics.MethodsPlasma levels of SHH from 20 normal healthy people and 64 patients with CKD stage 3-5 were measured by enzyme-linked immune...

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Published inLinchuang Shenzangbing Zazhi Vol. 22; pp. 89 - 93
Main Authors Zhu Yan-ting, Sun Yan, Wu Bing, Zhou Peng-hua, Chen Xin-tian, Dai Li-xia, Wang Qiong
Format Journal Article
LanguageChinese
Published Editorial Department of Journal of Clinical Nephrology 01.02.2022
Subjects
Chronic kidney disease
Serum
Sonic hedgehog
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Summary:ObjectiveTo examine the changes of plasma levels of sonic hedgehog （SHH） in patients with chronic kidney disease （CKD） stage 3-5 and explore the clinical characteristics.MethodsPlasma levels of SHH from 20 normal healthy people and 64 patients with CKD stage 3-5 were measured by enzyme-linked immune sorbent assay. And the changes of plasma level of SHH were examined. According to estimated glomerular filtration rate （eGFR），they were divided into different stages. The correlations were determined between SHH level and serum creatinine，blood urea nitrogen （BUN），eGFR and left ventricular mass index （LVMI）. Subsequently the changes of plasma levels of SHH were tested between left ventricular hypertrophy and non-left ventricular hypertrophy patients. Finally multi-factor analysis of left ventricular hypertrophy was performed.ResultsThe plasma concentration of SHH was significantly higher in CKD group than that in control group. The plasma level of SHH gradually increased with a lowering of eGFR. Obviously higher i
ISSN:1671-2390