COMPARATIVE EVALUATION OF CHRONIC RECURRENT FURUNCULOSIS AND PHAGOCYTIC COMPONENT OF IMMUNITY AMONG PATIENTS DIFFERING IN IgE LEVELS

The aim of this work was to compare clinical features of severity and some basic indicators of immune state in the patients with chronic recurrent furunculosis (CRF), differing in levels of serum immunoglobulin E (IgE). In cases with increased IgE levels, the clinical course proved to be more severe...

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Published inMedit͡s︡inskai͡a︡ immunologii͡a Vol. 16; no. 3; pp. 295 - 300
Main Authors T. A. Druzhinina, N. Yu. Alekseeva
Format Journal Article
LanguageRussian
Published St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 01.08.2014
Subjects
furunculosis
immunoglobulin e
neutrophils
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Summary:The aim of this work was to compare clinical features of severity and some basic indicators of immune state in the patients with chronic recurrent furunculosis (CRF), differing in levels of serum immunoglobulin E (IgE). In cases with increased IgE levels, the clinical course proved to be more severe, as characterized by persistent recurrence of infection, with multiple lesions and weak inflammatory reaction, as compared with patients with normal IgE levels. Meanwhile, additional purulent skin lesions were less common among patients from this group. Comparative evaluation of basic anti-pyogenic defense effects allowed us to show a significant decrease of induced chemiluminescence of whole heparinized blood (p < 0.05) in patients with increased IgE levels, thus regarding it as a potential factor of more severe CRF clinical course in this cohort of patients.
ISSN:1563-0625
2313-741X
DOI:10.15789/1563-0625-2014-3-295-300