INTERLEUKIN-6 AND DIABETIC NEPHROPATHY: PATHOGENIC INTERCONNECTIONS, TARGETS FOR NEPHROPROTECTION

The article summarizes recent data on the role of interleukin-6 (IL-6) in the development of diabetic nephropathy (DN) and related pathological conditions. The effects determined by the activation of membrane (IL-6R) and soluble (sIL-6R) receptors are described. Clinical and experimental studies of...

Full description

Saved in:
Bibliographic Details
Published inJuvenis scientia no. 12; pp. 14 - 18
Main Authors I. Yu. Pchelin, V. K. Bayrasheva, A. N. Shishkin, V. N. Vasilkova, N. V. Hudiakova
Format Journal Article
LanguageEnglish
Published Scientia Publishing House 01.12.2017
Subjects
chronic kidney disease
diabetes mellitus
diabetic nephropathy
insulin
insulin resistance
interleukin-6
tocilizumab
Online AccessGet full text

Cover

More Information
Summary:The article summarizes recent data on the role of interleukin-6 (IL-6) in the development of diabetic nephropathy (DN) and related pathological conditions. The effects determined by the activation of membrane (IL-6R) and soluble (sIL-6R) receptors are described. Clinical and experimental studies of the IL-6 interconnections with obesity, insulin resistance, renal fibrosis, cardiomyopathy and anemia are analyzed. The strategies of anti-inflammatory therapy and nephroprotection are discussed.
ISSN:2414-3782
2414-3790