Effect of ground black seeds (Nigella sativa L.) on renal tubular cell apoptosis induced by ischemia/reperfusion injury in the rats

Objective(s): The aim of this study was to evaluate the effects of ground black seeds on renal tubular cell apoptosis following ischemia/reperfusion (I/R) injury in rats. Materials and Methods: Forty male Wistar rats were randomly allocated into 5 equal groups including Sham, I/R model and three I/R...

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Bibliographic Details
Published inIranian journal of basic medical sciences Vol. 17; no. 12; pp. 1032 - 1035
Main Authors Ghafour Mousavi, Daryoush Mohajeri
Format Journal Article
LanguageEnglish
Published Mashhad University of Medical Sciences 01.12.2015
Subjects
Apoptosis Ischemia/reperfusion Kidney Nigella sativa Rat
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Summary:Objective(s): The aim of this study was to evaluate the effects of ground black seeds on renal tubular cell apoptosis following ischemia/reperfusion (I/R) injury in rats. Materials and Methods: Forty male Wistar rats were randomly allocated into 5 equal groups including Sham, I/R model and three I/R+ black seeds (5, 10 and 20%)-treated groups. I/R groups’ kidneys were subjected to 60 min of ischemia followed by 24 h of reperfusion. Microscopically, apoptosis of tubular cells was assessed by terminal deoxynucleotidyltransferase-mediated dUTP nick-end labelling (TUNEL) method. Results: The apoptotic cells of renal tubules were increased significantly (P
ISSN:2008-3866
2008-3874