Angiogenesis⁃ related factors expression in oral lichen planus

• Published in: Kou qiang ji bing fang zhi = Journal of prevention and treatment for stomatological diseases Vol. 25; no. 11; pp. 712 - 717
• Main Author: LI Juxiong
• Format: Journal Article
• Language: Chinese
• Published: Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases 01.11.2017
• Subjects: Angiogenesis; ELISA; ICAM⁃1; Oral lichen planus; VCAM⁃1; VEGF
• ISSN: 2096-1456; 2096-1456
• DOI: 10.12016/j.issn.2096⁃1456.2017.11.007

Objective To detect the expression of vascular endothelial growth factor (VEGF), intercellular adhesion molecule⁃1 (ICAM⁃1), vascular cell adhesion molecule⁃1 (VCAM⁃1) in oral lichen planus (OLP). Methods Thirty OLP patients and fifteen healthy subjects were enrolled in the study. Serum were collected from 15 healthy volunteers as con⁃ trols. Normal tissues were collected from surgical department as immunohistochemical analysis. The levels of VEGF, ICAM ⁃1, VCAM ⁃1 in serum were measured by ELISA. Immunohistochemical analysis of VEGF, ICAM ⁃ 1, VCAM⁃1 were carried out by the means of primary antibodies and anti⁃VEGF, anti⁃CD106 antigen (VCAM⁃1) and anti⁃CD54 anti⁃ gen (ICAM⁃1). Results ELISA results showed no expression differences for VEGF between the two groups. Whereas, the levels of ICAM⁃1, VCAM⁃1 in OLP group were significantly higher than those in control group (P < 0.05). Immuno⁃ histochemical results reveal the presence of a significant angiogenesis in OLP patients through the immunoexpression of VEGF