Multicentral pilot clinical trial of gliatilin in treatment of acute ischemic stroke

The multicentral pilot clinical trial of gliatilin in treatment ofacute ischemic stroke was held in 20062008 in Russia. The trialinvolved 122 patients, who received basic treatment and gliatilinduring 3 months after the stroke onset (115 days 2000 mg perday, 1630 days 1000 mg per day, 3190 days 800...

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Published inAnnaly kliničeskoj i èksperimentalʹnoj nevrologii (Online) Vol. 4; no. 1; pp. 20 - 28
Main Authors M. M. Odinak, I. A. Voznyuk, M. A. Piradov, S. A. Rumyantseva, A. N. Kuznetsov, S. N. Yanishevskiy, S. Yu. Golokhvastov, N. V. Tsygan
Format Journal Article
LanguageEnglish
Published Research Center of Neurology 01.02.2017
Subjects
brain infarct volume
clinical outcome
gliatilin
ischemic stroke
magnetic resonance imaging
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Summary:The multicentral pilot clinical trial of gliatilin in treatment ofacute ischemic stroke was held in 20062008 in Russia. The trialinvolved 122 patients, who received basic treatment and gliatilinduring 3 months after the stroke onset (115 days 2000 mg perday, 1630 days 1000 mg per day, 3190 days 800 mg perday). All patients underwent clinical examination (includingrepeated NIHSS, Rankin scale, Barthel index assessment), laboratoryand ultrasound examination, computer tomography ormagnetic resonance imaging during 24 hours after the strokeonset. 25 patients underwent repeated multimodal magnetic resonanceimaging (T1-, T2-, diffusion-, perfusion-weighted imaging).The results of examination of patients who received basictreatment alone were taken from literature. The trial resultsshow, that treatment of acute ischemic stroke with gliatilin promotesneurological recovery and increase of patients self-careability, which is probably concerned with the smaller final volumeof brain infarct.
ISSN:2075-5473
2409-2533
DOI:10.17816/psaic352