Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine

In this study, the first complexes of Zn(II) with the N-benzyloxycar- bonyl-S-alaninato ligand (N-Boc-S-ala) were synthesized. The new complexes were characterized by elemental analysis, conductometric measurements, IR, 1H-NMR, 13C-NMR and 2D-NMR spectroscopy. On the basis of the experimental data,...

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Bibliographic Details
Published inJournal of the Serbian Chemical Society Vol. 73; no. 8-9; pp. 815 - 824
Main Authors Mitić Dragana M., Miodragović Đenana U., Sladić Dušan M., Vitnik Željko J., Miodragović Zoran M., Anđelković Katarina K., Radulović Milanka Đ., Juranić Nenad O.
Format Journal Article
LanguageEnglish
Published Serbian Chemical Society 01.01.2008
Subjects
antimicrobial activity
dft
n-benzyloxycarbonyl-s-alanine
nmr
zn(ii) complexes
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Summary:In this study, the first complexes of Zn(II) with the N-benzyloxycar- bonyl-S-alaninato ligand (N-Boc-S-ala) were synthesized. The new complexes were characterized by elemental analysis, conductometric measurements, IR, 1H-NMR, 13C-NMR and 2D-NMR spectroscopy. On the basis of the experimental data, tetrahedral geometry of the Zn(II) complexes was proposed. A very good agreement between the NMR and DFT calculated data was obtained. Investigation of antimicrobial activity of the newly synthesized complexes was also performed. It was established that [Zn(N-Boc-S-ala)2] was selective and acts only on Candida albicans.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC0809815M