Establishment of reference intervals of squamous cell carcinoma antigen for healthy population in Nanning region

• Published in: Ji chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics Vol. 43; no. 12; pp. 1796 - 1800
• Main Author: ZHOU Dongyi, WEI Yuhong, YI Liling, WEI Shangmou, ZHU Chunling, YANG Sufang, PENG Qiliu
• Format: Journal Article
• Language: Chinese
• Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College 01.12.2023
• Subjects: squamous cell carcinoma antigen|reference interval|squamous cell carcinoma
• ISSN: 1001-6325
• DOI: 10.16352/j.issn.1001-6325.2023.12.1796

Objective To establish a reference intervals (RIs) of serum squamous cell carcinoma antigen(SCC-Ag) in healthy population in Nanning region and provide clinical evidence to support diagnosis and prognosis of squamous cell carcinoma. Methods A total of 10 197 reference individuals who joined a routine physical examination in the Health Management Center of Guangxi International Zhuang Medical Hospital from March 2019 to December 2021 were collected. The level of serum SCC-Ag was detected by chemiluminescence microparticle immunoassay. The Mann-Whitney U test was applied to compare the differences in serum SCC level between genders or adjacent age groups. The unilateral 95th percentile determined the upper limit of the RIs by the nonparametric method. Another 1 035 healthy subjects with the same conditions as the reference population were selected for refer- ence validation. Results The serum SCC-Ag level showed a skewed distribution (Z=0.08, P＜0.05). The serum SCC-Ag level of males was considerably higher than