Recent advances of morphogenesis and development in retinal pigment epithelium

The retinal pigment epithelium(RPE)is a pigmented simplecuboidal monolayer of epithelial cells that located between the photoreceptors in the neural retina and the Bruch's membrane in the vascular choroid and is critical for the survival and function of retinal photoreceptors. The pathogenesis...

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Published inGuo ji yan ke za zhi Vol. 14; no. 3; pp. 464 - 467
Main Authors Yan Zhang, Shao-Min Peng
Format Journal Article
LanguageEnglish
Published Press of International Journal of Ophthalmology (IJO PRESS) 01.03.2014
Subjects
development
retinal pigment epithelium
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Abstract The retinal pigment epithelium(RPE)is a pigmented simplecuboidal monolayer of epithelial cells that located between the photoreceptors in the neural retina and the Bruch's membrane in the vascular choroid and is critical for the survival and function of retinal photoreceptors. The pathogenesis of multiple congenital RPE diseases is closely related to embryonic development. This review summarized the current knowledge of the molecular mechanisms controlling early steps of RPE development, with emphasis on basic process, critical signaling molecules, key transcription factors and pathway maintaining the RPE cell fate.
AbstractList The retinal pigment epithelium(RPE)is a pigmented simplecuboidal monolayer of epithelial cells that located between the photoreceptors in the neural retina and the Bruch's membrane in the vascular choroid and is critical for the survival and function of retinal photoreceptors. The pathogenesis of multiple congenital RPE diseases is closely related to embryonic development. This review summarized the current knowledge of the molecular mechanisms controlling early steps of RPE development, with emphasis on basic process, critical signaling molecules, key transcription factors and pathway maintaining the RPE cell fate.
Author Shao-Min Peng
Yan Zhang
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  organization: Department of Ophthalmology, Inner Mongolia Forestry General Hospital, Yakeshi 022150, Inner Mongolia Autonomous Region, China
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  organization: Department of Ophthalmology, the 2nd Affiliated Hospital of Harbin Medical Hospital, Harbin 150000, Heilongjiang Province, China
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retinal pigment epithelium
Title Recent advances of morphogenesis and development in retinal pigment epithelium
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