Recent advances of morphogenesis and development in retinal pigment epithelium

The retinal pigment epithelium(RPE)is a pigmented simplecuboidal monolayer of epithelial cells that located between the photoreceptors in the neural retina and the Bruch's membrane in the vascular choroid and is critical for the survival and function of retinal photoreceptors. The pathogenesis...

Full description

Saved in:
Bibliographic Details
Published inGuo ji yan ke za zhi Vol. 14; no. 3; pp. 464 - 467
Main Authors Yan Zhang, Shao-Min Peng
Format Journal Article
LanguageEnglish
Published Press of International Journal of Ophthalmology (IJO PRESS) 01.03.2014
Subjects
development
retinal pigment epithelium
Online AccessGet full text

Cover

More Information
Summary:The retinal pigment epithelium(RPE)is a pigmented simplecuboidal monolayer of epithelial cells that located between the photoreceptors in the neural retina and the Bruch's membrane in the vascular choroid and is critical for the survival and function of retinal photoreceptors. The pathogenesis of multiple congenital RPE diseases is closely related to embryonic development. This review summarized the current knowledge of the molecular mechanisms controlling early steps of RPE development, with emphasis on basic process, critical signaling molecules, key transcription factors and pathway maintaining the RPE cell fate.
ISSN:1672-5123
1672-5123
DOI:10.3980/j.issn.1672-5123.2014.03.22