A New Exploration for Evaluating the Stability of Warfarin Anticoagulation Therapy: Based on Modified SAMe-T-PDW2-LAD2 Score

• Published in: Zhongguo quanke yixue Vol. 27; no. 33; pp. 4112 - 4118
• Main Author: ZHOU Qibao, LUO Xiao, CHEN Ling, HE Huabin, YUAN Mingqing
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01.11.2024
• Subjects: anticoagulants|warfarin|atrial fibrillation|modified same-t-pdw2-lad2 score|same-tt2r2 score|time within therapeutic range
• ISSN: 1007-9572
• DOI: 10.12114/j.issn.1007-9572.2023.0750

Background At present, there are few studies on the stability of warfarin anticoagulation therapy. The main evaluation method is SAMe-TT2R2 score, but it has obvious limitations and is not applicable to non-white population. Previous studies have shown that platelet distribution width (PDW) and left atrial diameter (LAD) are closely related to time within therapeutic range (TTR). Whether they can be incorporated into the existing scoring system and improved is worthy of clinical reflection. Objective To explore the predictive value of modified SAMe-T-PDW2-LAD2 score for the percentage of TTR of common international normalized ratio (INR) for the stability of warfarin anticoagulation therapy. Methods A total of 164 patients with persistent nonvalvular atrial fibrillation who were treated with warfarin anticoagulation in Jiujiang NO.1 People's Hospital from January 2021 to June 2023 were selected as the research objects. TTR≥65% was defined as high quality anticoagulation. TTR<65% was defined as substandard, th