Pengujian Toksisitas Akut Oral Dan Dermal pada Biolarvasida Metarhizium anisopliae terhadap Tikus Putih Spraque Dawley

• Published in: Al-Kauniyah Vol. 7; no. 1; pp. 1 - 8
• Main Author: Deni Zulfiana
• Format: Journal Article
• Language: English
• Published: Universitas Islam Negeri Syarif Hidayatullah Jakarta 01.04.2014
• Subjects: Biolarvacide; Metarhizium anisopliae; toxixity test
• ISSN: 1978-3736; 2502-6720
• DOI: 10.15408/kauniyah.v7i1.2706

Acute oral and dermal toxicity test against white rats was conducted to determine the toxicity and side effects of bio-larvacide (Metarhizium anisopliae crude extract) on humans. In the oral test used a maximum dose 5000 mg/kg and dermal testing used a maximum dose of 2000 mg/kg. Dose treatment and control tested to 5 Spraque Dawley male rats. The results showed that oral treatment with a dose of 5000 mg/kg did not cause mortality and did not cause changes in anatomic pathology of viceral organs. In the dermal treatment with a dose of 2000 mg/kg did not cause mortality and did not cause changes in anatomic pathology of viceral organs. Based on these results LD50 acute oral M. anisopliae biolarvacide above 5000 mg/kg and the acute dermal is above 2000 mg/kg. It was therefore concluded that the formulation of Metarhizium anisopliae biolarvasida classified as not hazardous when used in accordance with the recommendation of the class I (WHO, 2003).