Influence of hyperuricemia on the reproductive function of female rats and its mechanism

• Published in: 精准医学杂志 Vol. 39; no. 3; pp. 213 - 217
• Main Author: GONG Xuelin, ZOU Tong, SONG Miao, LIU Chengyang, ZHANG Qing, SUN Yu, XING Shichao
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of Precision Medicine 01.06.2024
• Subjects: hyperuricemia|estrus|gonadal steroid hormones|cytokines|inflammation|oxidative stress|females|rats, wistar
• ISSN: 2096-529X
• DOI: 10.13362/j.jpmed.202403006

Objective To investigate the influence of hyperuricemia (HUA) on the reproductive function of female rats and its mechanism. Methods A total of 18 female Wistar rats were randomly divided into HUA group, HUA recovery group (HR group), and control group (N group), with 6 rats in each group. The rats in the HUA group and the HR group were given intragastric administration of 50 mg/kg uric acid and intraperitoneal injection of 250 mg/kg oteracil potassium every day, and since week 9, the rats in the HR group were given an equal volume of normal saline by gavage and intraperitoneal injection, while the treatment remained unchanged for those in the HUA group, for another 7 weeks; the rats in the N group were given an equal vo-lume of normal saline by gavage and intraperitoneal injection for 16 weeks. At week 16, body weight, uterine mass, and ovarian mass were measured for all three groups, and uterine and ovarian coefficients were calculated; hematoxylin-eosin staining was used to observe the pathological changes