The Effects of Bisphosphonate Therapy on Upper Gastrointestinal Tract in Postmenopausal Women: A Preliminary Report

The aim of this study was to evaluate adverse effects of risedronate, which is effective in the treatment of the osteoporosis, using endoscopic and histopathologic examinations. In all subjects, the endoscopic appearance of the esophageal, gastric and duodenal mucosa was evaluated before the treatme...

Full description

Saved in:
Bibliographic Details
Published inTurkish journal of osteoporosis Vol. 8; no. 3; pp. 125 - 127
Main Authors Zeliha Ünlü, Murat Saruç, Nurten Türkel Küçükmetin, Işıl Tuzcuoğlu, Mengü Sarıoğlu, Semin Ayhan, Çiğdem Tüzün, Hakan Yüceyar
Format Journal Article
LanguageEnglish
Published Galenos Yayinevi 01.09.2002
Subjects
bisphosphonates
gastric damage
Osteoporosis
Online AccessGet full text

Cover

More Information
Summary:The aim of this study was to evaluate adverse effects of risedronate, which is effective in the treatment of the osteoporosis, using endoscopic and histopathologic examinations. In all subjects, the endoscopic appearance of the esophageal, gastric and duodenal mucosa was evaluated before the treatment. Subjects who had normal endoscopic examination results were given 5 mg/day risedronate, 1000mg/day calcium and 400IU/day vitamin D medication. Endoscopic examinations of eight patients were repeated 1 month later. Control endoscopic and histopathologic examinations revealed gastric damage in 5 of the 8 patients. In conclusion, this preliminary report showed that we should be aware of the gastric damage due to risedronate therapy in the short term period.
ISSN:2147-2653