ROLE OF MICROENVIRONMENT IN THE DEVELOPMENT AND PROGRESSION OF PANCREATIC CANCER

Pancreatic cancer is a highly aggressive malignancy with metastatic potential and poor response to chemotherapy. Unfortunately, molecular-based targeted therapies failed to make significant progress against pancreatic cancer. One of the promising subjects of molecular oncology is the study of tumor...

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Published inSibirskiĭ onkologicheskiĭ zhurnal Vol. 15; no. 3; pp. 82 - 90
Main Authors E. V. Okladnikova, T. G> Ruksha
Format Journal Article
LanguageRussian
Published Russian Academy of Sciences, Tomsk National Research Medical Center 01.07.2016
Subjects
микроокружение опухоли
рак поджелудочной железы
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Summary:Pancreatic cancer is a highly aggressive malignancy with metastatic potential and poor response to chemotherapy. Unfortunately, molecular-based targeted therapies failed to make significant progress against pancreatic cancer. One of the promising subjects of molecular oncology is the study of tumor microenvironment modulation for therapeutic purposes. In the present review, the description of pancreatic cancer microenvironment is provided, including intercellular interaction regulation which is important for tumor growth and progression. The study of this topic is important for the development of new therapies for pancreatic cancer.
ISSN:1814-4861
2312-3168
DOI:10.21294/1814-4861-2016-15-3-85-92