Effect and safety of platelet-rich plasma injection combined with pregabalin in the treatment of knee osteoarthritis

• Published in: Zhongguo shu xue za zhi Vol. 35; no. 12; pp. 1239 - 1243
• Main Authors: Juan CHEN, Hongbing LI, Zhou CHEN
• Format: Journal Article
• Language: Chinese
• Published: Institute of Blood Transfusion of Chinese Academy of Medical Sciences 01.12.2022
• Subjects: knee function; knee osteoarthritis; pain; platelet-rich plasma; pregabalin
• ISSN: 1004-549X
• DOI: 10.13303/j.cjbt.issn.1004-549x.2022.12.012

Objective To explore the effects of platelet-rich plasma (PRP) injection combined with pregabalin on pain and knee function in knee osteoarthritis (KOA). Methods A total of 220 patients with KOA in our hospital, between June 2020 and April 2022, were enrolled and randomly divided into observation group (n=110) and the control (n=110). The observation group was given PRP injection combined with pregabalin, while control group was given sodium hyaluronate combined with pregabalin. The clinical curative effect, osteoarthritis index (WOMAC), pain level (VAS), knee function [Lysholm-Ⅱ scale, Rasmussen scale], levels of repair-promoting factors [transforming growth factor-β1 (TGF-β1), bone morphogenetic protein 4 (BMP4), insulin growth factor 1 (IGF-1)], inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor α (TNF-α)], oxidative stress indexes [superoxide dismutase (SOD), nitric oxide (NO)] and blood routine [white blood cell count (WBC), platelet count (Plt)], and the occurrence of adverse reactions in