Effects of multi-oil fat emulsion injection on liver function, immune function and inflammation in ICU patients

• Published in: Di 3 jun yi da xue xue bao Vol. 42; no. 3; pp. 273 - 277
• Main Authors: ZHU Wenyi, FAN Rong, LI Li, WANG Xiangyu, XU Jing, HU Mingdong, LI Qi, WANG Jian
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of Third Military Medical University 01.02.2020
• Subjects: critically ill patients; immune function; inflammatory; liver function; multi-oil fat emulsion injection
• ISSN: 1000-5404
• DOI: 10.16016/j.1000-5404.201909070

Objective To investigate the effects of multi-oil fat emulsion injection on liver function, immune function and inflammation in intensive care unit (ICU) patients. Methods Eighty-four ICU patients admitted in the Department of Pulmonary and Critical Care Medicine of our hospital from June 2017 to September 2018 were prospectively recruited in this study. They were randomly divided into experimental group (n=42) and control group (n=42). The patients of both groups were given enteral nutrition+parenteral nutrition, and the fat emulsion was medium-long chain fat emulsion in the control group, and multi-oil fat emulsion in the experimental group. The energy and protein intake were basically similar in the patients of the 2 groups, and the nutritional support time was 7 days. Results The experimental group had significantly lower content of total bilirubin (22.2±5.5 vs 31.3±7.4 μmol/L, P < 0.05), increased counts of CD4 cells (442.3±31.4 vs 322.1±23.7, P < 0.05) and CD8 cells (289.7±23.4 vs 223.1±16.6, P < 0.05),