Clinical Characteristics and Risk Factors of Normocalcemic Primary Hyperparathyroidism

• Published in: Zhongguo quanke yixue Vol. 26; no. 11; pp. 1369 - 1374
• Main Author: HUANG Zeyu, SU Lei, SANG Jianfeng, ZHAO Ru, HAN Chen, WANG Qian, GU Tianwei, BI Yan, ZHU Dalong, SHEN Shanmei
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01.04.2023
• Subjects: hyperparathyroidism, primary|normocalcemic primary hyperparathyroidism|bone metabolism|glucose metabolism disorders|root cause analysis|disease attributes
• ISSN: 1007-9572
• DOI: 10.12114/j.issn.1007-9572.2022.0712

Background Normocalcemic primary hyperparathyroidism (NCPHPT), as a new phenotype of primary hyperparathyroidism (PHPT), has gained increasing attention. NCPHPT is easily misdiagnosed in clinical practice, and its risk factors need to be evaluated further. Objective To investigate the clinical features of NCPHPT and to explore its risk factors. Methods Patients diagnosed with PHPT (n=153) were retrospectively selected from Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School from January 2016 to December 2021, and divided into an experimental group (NCPHPT group) and a hypercalcemia PHPT group according to the corrected total serum calcium level. Meanwhile, individuals undergoing physical examination with normal parathyroid function were selected as the control group. The differences in clinical characteristics, glucose and bone metabolism, imaging and pathology results among the groups were compared. Multivariate Logistic regression analysis was used to analyze the risk f