Association between urinary excretion of protein-bound uremic toxins and upper urinary tract calculus

• Published in: Shanghai jiao tong da xue xue bao. Yi xue ban Vol. 44; no. 5; pp. 591 - 598
• Main Authors: WANG Wenji, ZHONG Kaiyi, LI Jiaolun, ZHOU Yueling, HUANG Tao, DUAN Lizhu, SHEN Yuqi, LI Xuezhu, DING Feng, XIE Danshu
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) 01.05.2024
• Subjects: indole-3-acetic acid (iaa); indoxyl sufate (is); p-cresol sulfate (pcs); protein-bound uremic toxin (pbut); renal tubular secretion; upper urinary tract calculus
• ISSN: 1674-8115
• DOI: 10.3969/j.issn.1674-8115.2024.05.007

Objective·To investigate the relation between urinary excretion of protein-bound uremic toxins (PBUTs) and upper urinary tract calculus.Methods·Residents aged 18‒80 years in the community of Haitou, Danzhou city in Hainan Province were recruited. Basic information and diet for the last 3 d of the subjects were recorded. Their fasting sera and 24-hour urine samples were collected, and they also underwent ultrasound examination of kidneys and ureters. The subjects with upper urinary calculi detected by ultrasound or a clear history of upper urinary calculi were selected as the calculus group, and the others as the non-calculus group. The biochemical indicators related to the formation of calculus in blood and urine were detected, and the levels of PBUTs, including indoxyl sufate (IS), indole-3-acetic acid (IAA), and p-cresol sulfate (PCS) in blood and urine, as well as oxalic acid and citric acid in urine were detected by high-performance liquid chromatography. The related factors of upper urinary tract calculu