Antibacterial activity of ajwain oil on multidrug-resistant Enterobacteriaceae isolated from human faeces

The aims of this study were to evaluate the effects of ajwain oil on multidrug-resistant (MDR) Enterobacteriaceae isolated from human faeces, the mode of action, and the active components. The studies also include the methicillin-resistant Staphylococcus aureus (MRSA). The ajwain oil showed broad sp...

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Published inWārasān Songkhlā Nakharin Vol. 44; no. 3; pp. 785 - 793
Main Authors Nalin Wongkattiya, Phanchana Sanguansermsri, Kanit Assawatheptawee, Pannika Ritvirool Niumsup, Ian Hamilton Fraser, Donruedee Sanguansermsri
Format Journal Article
LanguageEnglish
Published Prince of Songkla University 01.06.2022
Subjects
ajwain oil
antibacterial activity
multidrug-resistant bacteria
thymol
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Summary:The aims of this study were to evaluate the effects of ajwain oil on multidrug-resistant (MDR) Enterobacteriaceae isolated from human faeces, the mode of action, and the active components. The studies also include the methicillin-resistant Staphylococcus aureus (MRSA). The ajwain oil showed broad spectrum and strong antibacterial activity against all the bacteria tested. The ajwain oil contained at least nine chemical compounds, and thymol was shown to be the most active component against all tested bacteria. Time-kill assay showed bactericidal effect and over 2 log reduction of MRSA and MDR Enterobacteriaceae after exposure to the ajwain oil for 30 and 10 minutes, respectively (1x, 2x, and 4x MIC). The scanning electron micrograph of MRSA and MDR Escherichia coli demonstrated bacterial cellular destruction after one-hour exposure to the 1x MIC of ajwain oil. Our results suggest that the application of ajwain oil may have potential for control and treatment of antibiotic resistant bacteria.
ISSN:0125-3395
DOI:10.14456/sjst-psu.2022.105