Study on the Value of Oligosaccharide Chain and Alpha-fetoprotein for Risk Screening and Diagnosis of Hepatitis B Virus-related Hepatocellular Carcinoma

• Published in: Zhongguo quanke yixue Vol. 27; no. 15; pp. 1855 - 1860
• Main Author: ZHANG Yun, CAI Xinyi, DING Jingnuo, LU Shengwei, CHEN Cuiying, WU Tingting, ZHANG Junli, ZHAO Weifeng
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01.05.2024
• Subjects: carcinoma, hepatocellular|hepatitis b virus|alpha-fetoproteins|g-test|cancer screening|early diagnosis|roc curve
• ISSN: 1007-9572
• DOI: 10.12114/j.issn.1007-9572.2023.0239

Background Hepatocellular carcinoma (HCC) is the main pathological type of primary liver cancer (PLC) and is closely associated with Hepatitis B virus (HBV) infection. HCC in its early stages often presents no significant symptoms and is usually discovered at an advanced stage with liver, portal vein, or other site metastases, leading to a poor prognosis. Regular screening and early diagnosis in high-risk populations in the early stages of the disease are of great significance for clinical treatment and prognosis. Objective To explore the application value of oligosaccharides and alpha-fetoprotein (AFP) in the risk population and patients of HBV-related HCC, providing a reference for clinical diagnosis. Methods The study included 165 chronic HBV infection patients treated at the First Affiliated Hospital of Soochow University from January to November 2022, comprising 123 non-HCC and 42 HCC patients. Patient data (age, gender, cirrhosis status), laboratory indices[total bilirubin (TB), albumin (ALB), platelet