Sex-specific Analysis of Influencing Factors for the Association between Baseline Serum Uric Acid and Two-year Outcome after First Acute Ischemic Stroke

• Published in: Zhongguo quanke yixue Vol. 26; no. 5; pp. 557 - 562
• Main Author: YAO Huihui, SHU Lin, YAO Linli, LI Sha, YANG Xiaotong, LI Yunchun
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01.02.2023
• Subjects: brain infarction|uric acid|recurrence|all-cause death|brain diseases|prognosis|root cause analysis|stroke
• ISSN: 1007-9572
• DOI: 10.12114/j.issn.1007-9572.2022.0582

Background The level of serum uric acid (SUA) has recently been proven to be associated with outcomes in patients with acute ischemic stroke (AIS) , but whether the association is still controversial. Objective To explore the relationship of baseline SUA level with two-year recurrence and all-cause mortality after first AIS. Methods This retrospective study was conducted with a cohort of inpatients with first AIS treated in Department of Neurology, University of Hong Kong-Shenzhen Hospital from January 1, 2018 to December 31, 2019. The general information, biochemical indicators, and two-year adverse outcome (recurrence and all-cause mortality) after first AIS were collected and a follow up until December 31, 2021. Logistic regression analysis was used to explore the relationship of adverse outcome with quartile of baseline SUA levels〔Q1 group (n=129) , Q2 group (n=129) , Q3 group (n=128) , Q4 group (n=127) 〕 by sex. Results Univariate Logistic regression analysis showed that advanced age, history of diabetes